To remove the fuzziness in the boundaries of the solubilitypermeability frame of reference, a dataset of 85 oral drugs from all four classes of BCS are mapped into new frames of references in which the coordinate axes are based on the rates of dissolution, systemic elimination (metabolism), and membrane permeation.

BCS Classification.

P e rme a bility.

There are a few BCS class 2 and class 4 compounds that are formulated as.

Criteria may expand the number of Class 1 drugs eligible for a biowaiver of in vivo bioequivalence (BE) studies and provide predictability of drug disposition profiles for Classes 2, 3, and 4 compounds.

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American Institute of Chemical Engineers AIChE J, 61: 35703579, 2015.

Reducing the size of the solid-state particles increases their dissolution and transport rate across the mucus barrier and the aqueous boundary layer.

This review compares the absorption mechanisms of nano- and larger particles in the lumen at different prandial states, with an emphasis on data derived from in vivo models.

Four BSC class II drugsaprepitant, cyclosporine, danazol and fenofibrateare discussed in detail based on information from preclinical intestinal perfusion models.

Bcs Class 2 Drug